![]() In humans, there is a large variation in daily amounts of fluids consumed and worldwide surveys find that a large proportion of people do not consume the recommended amounts and are hypohydrated. 10 The shortened life span was accompanied by accelerated degenerative changes within multiple organ systems of the chronically hypohydrated mice. 9 This hypothesis was inspired by previous mouse studies in which lifelong water restriction, increasing serum sodium by 5 mmol/l, shortened the mouse lifespan by 6 months which corresponds to about 15 years of human life. Here, we define hypohydration as a state in which water conservation mechanisms, including the secretion of antidiuretic hormone and renal urine concertation, are activated when low water intake or high water loss result in decreased body water content and elevated plasma tonicity. In the current study, we test the hypothesis that optimal hydration may slow down the aging process. 1, 2, 3 Disparities in the pace of biological aging are already detectable at midlife 6 indicating that preventive measures that can be applied early in life would be most effective to slow down the aging processes and decrease the burden of chronic diseases. Accumulating findings suggest that slowing the aging processes and extending healthy life span has a potential to improve quality of life and decrease health care cost to a substantially greater degree than a cure of any single disease. 1, 2, 3, 4, 5 A new research field of geroscience aims to develop safe, practical, and widely available interventions targeting aging: a common driver of chronic diseases. Increased risk of mortality after 3–6 years of follow-up was demonstrated among people with serum sodium in the upper end of normal range.įinding and implementing preventive measures that can slow down the aging process is currently recognized as a major challenge of preventive medicine to combat the epidemic of age-dependent chronic diseases that is emerging as a result of a rapidly aging world population. Several observational epidemiological studies identified associations of the hydration markers with future development of heart failure, metabolic disease and mortality. We did not find studies relating markers of subclinical hypohydration at middle age with the speed of biological aging. We also were looking for studies estimating biological age in relation to the markers of habitual low hydration such as serum sodium. We searched PubMed, and Web of Science, without any language restriction using combinations of the terms “serum sodium,” “hydration,” “aging,” “biological aging,” “chronic diseases,” “mortality.” We focused on finding studies assessing associations between the hydration status of healthy people at middle age or younger with a long-term aging-related outcomes such as future development of chronic diseases or premature mortality. Treatment for hyponatremia may include fluid and electrolyte replacement, medication adjustments, and addressing the underlying cause.In this study, we aimed to evaluate pro-aging effects of mild subclinical hypohydration that activates water conservation mechanisms leading to the excretion of lower volume of more concentrated urine but does not elevate plasma sodium and osmolality beyond normal ranges. Symptoms of hyponatremia can include headache, nausea, confusion, seizures, and coma. This can be caused by a number of factors, including excessive fluid intake, medications that affect electrolyte balance, and certain medical conditions such as kidney disease or heart failure. Hyponatremia: Hyponatremia occurs when the level of sodium in the blood is too low, typically below 135 mEq/L.Treatment for hypernatremia may include fluid and electrolyte replacement and addressing the underlying cause. Symptoms of hypernatremia can include thirst, restlessness, confusion, seizures, and coma. This can be caused by a number of factors, including excessive sodium intake, dehydration, and certain medical conditions such as diabetes insipidus. Hypernatremia: Hypernatremia occurs when the level of sodium in the blood is too high, typically above 145 mEq/L.The two main types of abnormal sodium levels are hypernatremia and hyponatremia. Abnormal sodium levels in the blood can be caused by a number of factors, including dehydration, medication use, hormonal imbalances, and certain medical conditions.
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